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Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction
Changes in telomere chromatin have been linked to cellular senescence, but the underlying mechanisms and impact on lifespan are unclear. We found that inactivation of the Sas2 histone acetyltransferase delays senescence in Saccharomyces cerevisiae telomerase (tlc1) mutants through a homologous recom...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808364/ https://ncbi.nlm.nih.gov/pubmed/19875981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.314 |
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