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Histone depletion prevents telomere fusions in pre-senescent cells
Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome during pre-senescence by preventing telomere-telomere fusions (T-TFs) and the subsequent genet...
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| Publicado en: | PLoS Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5991667/ https://ncbi.nlm.nih.gov/pubmed/29879139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007407 |
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