A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis

Inflammatory bowel disease (IBD) is a high-risk condition for human colorectal cancer. However, our mechanistic understanding of the link between inflammation and tumorigenesis in the colon is limited. Here we established a novel mouse model of colitis-associated cancer by genetically inactivating s...

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Hoofdauteurs: Deng, Lin, Zhou, Jin-Feng, Sellers, Rani S., Li, Jiu-Feng, Nguyen, Andrew V., Wang, Yubao, Orlofsky, Amos, Liu, Qiang, Hume, David A., Pollard, Jeffrey W., Augenlicht, Leonard, Lin, Elaine Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Investigative Pathology 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808099/
https://ncbi.nlm.nih.gov/pubmed/20042677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090622
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