Liver-Specific β-Catenin Knockout Mice Exhibit Defective Bile Acid and Cholesterol Homeostasis and Increased Susceptibility to Diet-Induced Steatohepatitis

Although the role of Wnt/β-catenin signaling in liver growth and development is well established, its contribution in non-neoplastic hepatic pathologies has not been investigated. Here, we examine the role of β-catenin in a murine model of diet-induced liver injury. Mice with hepatocyte-specific β-c...

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Detalhes bibliográficos
Main Authors: Behari, Jaideep, Yeh, Tzu-Hsuan, Krauland, Lindsay, Otruba, Wade, Cieply, Benjamin, Hauth, Beth, Apte, Udayan, Wu, Tong, Evans, Rhobert, Monga, Satdarshan P.S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808081/
https://ncbi.nlm.nih.gov/pubmed/20019186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090667
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