Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension

BACKGROUND: In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to increased pulmonary vascular and airway tonus and to local inflammation. Bosentan (E...

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Autori principali: Droste, Annette S, Rohde, David, Voelkers, Mirko, Filusch, Arthur, Bruckner, Thomas, Borst, Mathias M, Katus, Hugo A, Meyer, F Joachim
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807428/
https://ncbi.nlm.nih.gov/pubmed/20042085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-10-129
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