Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase, regulating MAPkinase signalling, in which cancer-associated mutations have never been reported. In this study, 174 primary gastrointestinal cancers (48 hereditary and 126 sporadic forms) and 7 colorectal cancer cell lines were screened for...

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Main Authors: Velho, Sérgia, Oliveira, Carla, Paredes, Joana, Sousa, Sónia, Leite, Marina, Matos, Paulo, Milanezi, Fernanda, Ribeiro, Ana Sofia, Mendes, Nuno, Licastro, Danilo, Karhu, Auli, Oliveira, Maria José, Ligtenberg, Marjolijn, Hamelin, Richard, Carneiro, Fátima, Lindblom, Annika, Peltomaki, Paivi, Castedo, Sérgio, Schwartz, Simó, Jordan, Peter, Aaltonen, Lauri A., Hofstra, Robert M.W., Suriano, Gianpaolo, Stupka, Elia, Fialho, Arsenio M., Seruca, Raquel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807374/
https://ncbi.nlm.nih.gov/pubmed/19955118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp536
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