Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase, regulating MAPkinase signalling, in which cancer-associated mutations have never been reported. In this study, 174 primary gastrointestinal cancers (48 hereditary and 126 sporadic forms) and 7 colorectal cancer cell lines were screened for...

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主要な著者: Velho, Sérgia, Oliveira, Carla, Paredes, Joana, Sousa, Sónia, Leite, Marina, Matos, Paulo, Milanezi, Fernanda, Ribeiro, Ana Sofia, Mendes, Nuno, Licastro, Danilo, Karhu, Auli, Oliveira, Maria José, Ligtenberg, Marjolijn, Hamelin, Richard, Carneiro, Fátima, Lindblom, Annika, Peltomaki, Paivi, Castedo, Sérgio, Schwartz, Simó, Jordan, Peter, Aaltonen, Lauri A., Hofstra, Robert M.W., Suriano, Gianpaolo, Stupka, Elia, Fialho, Arsenio M., Seruca, Raquel
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2010
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Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807374/
https://ncbi.nlm.nih.gov/pubmed/19955118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp536
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