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Location of 3-Hydroxyproline Residues in Collagen Types I, II, III, and V/XI Implies a Role in Fibril Supramolecular Assembly

Collagen triple helices are stabilized by 4-hydroxyproline residues. No function is known for the much less common 3-hydroxyproline (3Hyp), although genetic defects inhibiting its formation cause recessive osteogenesis imperfecta. To help understand the pathogenesis, we used mass spectrometry to ide...

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Main Authors: Weis, Mary Ann, Hudson, David M., Kim, Lammy, Scott, Melissa, Wu, Jiann-Jiu, Eyre, David R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807315/
https://ncbi.nlm.nih.gov/pubmed/19940144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.068726
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