The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule

The hedgehog (HH) family of ligands plays an important instructional role in metazoan development. HH proteins are initially produced as ∼45-kDa full-length proteins, which undergo an intramolecular cleavage to generate an amino-terminal product that subsequently becomes cholesterol-modified (HH-Np)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tokhunts, Robert, Singh, Samer, Chu, Tehyen, D'Angelo, Gisela, Baubet, Valerie, Goetz, John A., Huang, Zhen, Yuan, Ziqiang, Ascano, Manuel, Zavros, Yana, Thérond, Pascal P., Kunes, Sam, Dahmane, Nadia, Robbins, David J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Molecular Basis of Cell and Developmental Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807313/
https://ncbi.nlm.nih.gov/pubmed/19920144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078626
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