The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule

The hedgehog (HH) family of ligands plays an important instructional role in metazoan development. HH proteins are initially produced as ∼45-kDa full-length proteins, which undergo an intramolecular cleavage to generate an amino-terminal product that subsequently becomes cholesterol-modified (HH-Np)...

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Detalhes bibliográficos
Main Authors: Tokhunts, Robert, Singh, Samer, Chu, Tehyen, D'Angelo, Gisela, Baubet, Valerie, Goetz, John A., Huang, Zhen, Yuan, Ziqiang, Ascano, Manuel, Zavros, Yana, Thérond, Pascal P., Kunes, Sam, Dahmane, Nadia, Robbins, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807313/
https://ncbi.nlm.nih.gov/pubmed/19920144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078626
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