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The Neurospora Peptide:N-Glycanase Ortholog PNG1 Is Essential for Cell Polarity despite Its Lack of Enzymatic Activity

Secretory proteins are subjected to a stringent endoplasmic reticulum-based quality control system that distinguishes aberrant from correctly folded proteins. The cytoplasmic peptide:N-glycanase cleaves oligosaccharides from misfolded glycoproteins and prepares them for degradation by the 26 S prote...

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Main Authors: Maerz, Sabine, Funakoshi, Yoko, Negishi, Yuki, Suzuki, Tadashi, Seiler, Stephan
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807290/
https://ncbi.nlm.nih.gov/pubmed/19940117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045302
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