The Central Portion of Factor H (Modules 10–15) Is Compact and Contains a Structurally Deviant CCP Module

The first eight and the last two of 20 complement control protein (CCP) modules within complement factor H (fH) encompass binding sites for C3b and polyanionic carbohydrates. These binding sites cooperate self-surface selectively to prevent C3b amplification, thus minimising complement-mediated dama...

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Main Authors: Schmidt, Christoph Q., Herbert, Andrew P., Mertens, Haydyn D.T., Guariento, Mara, Soares, Dinesh C., Uhrin, Dusan, Rowe, Arthur J., Svergun, Dmitri I., Barlow, Paul N.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806952/
https://ncbi.nlm.nih.gov/pubmed/19835885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.010
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