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Therapeutic Efficacy of Cintredekin Besudotox (IL13-PE38QQR) in Murine Lung Fibrosis Is Unaffected by Immunity to Pseudomonas aeruginosa Exotoxin A

BACKGROUND: We have previously explored a therapeutic strategy for specifically targeting the profibrotic activity of IL-13 during experimental pulmonary fibrosis using a fusion protein comprised of human IL-13 and a mutated form of Pseudomonas aeruginosa exotoxin A (IL13-PE) and observed that the i...

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Detalhes bibliográficos
Main Authors: Rosada, Rogério S., Moreira, Ana P., Frantz, Fabiani G., Puri, Raj K., Rahman, Aquilur, Standiford, Theodore J., Zárate-Bladés, Carlos R., Silva, Célio L., Hogaboam, Cory M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806906/
https://ncbi.nlm.nih.gov/pubmed/20090941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008721
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