Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

Utilizing subcutaneous tumor models, we previously validated SPARC (secreted protein acidic and rich in cysteine) as a key component of the stromal response, where it regulated tumor size, angiogenesis and extracellular matrix deposition. In the present study, we demonstrate that pancreatic tumors g...

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Detalhes bibliográficos
Main Authors: Arnold, Shanna A., Rivera, Lee B., Miller, Andrew F., Carbon, Juliet G., Dineen, Sean P., Xie, Yang, Castrillon, Diego H., Sage, E. Helene, Puolakkainen, Pauli, Bradshaw, Amy D., Brekken, Rolf A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806901/
https://ncbi.nlm.nih.gov/pubmed/20007485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.003228
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