Mutational analysis of molecular requirements for the actions of general anaesthetics at the γ-aminobutyric acid(A )receptor subtype, α1β2γ2

BACKGROUND: Amino acids in the β subunit contribute to the action of general anaesthetics on GABA(A )receptors. We have now characterized the phenotypic effect of two β subunit mutations in the most abundant GABA(A )receptor subtype, α1β2γ2. RESULTS: The β2(N265M) mutation in M2 decreased the modula...

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Udgivet i:BMC Pharmacol
Main Authors: Siegwart, Roberta, Krähenbühl, Karin, Lambert, Sachar, Rudolph, Uwe
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2003
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280653/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14613517/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2210-3-13
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