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Mutational analysis of molecular requirements for the actions of general anaesthetics at the γ-aminobutyric acid(A )receptor subtype, α1β2γ2
BACKGROUND: Amino acids in the β subunit contribute to the action of general anaesthetics on GABA(A )receptors. We have now characterized the phenotypic effect of two β subunit mutations in the most abundant GABA(A )receptor subtype, α1β2γ2. RESULTS: The β2(N265M) mutation in M2 decreased the modula...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC280653/ https://ncbi.nlm.nih.gov/pubmed/14613517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-3-13 |
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