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Mutational analysis of molecular requirements for the actions of general anaesthetics at the γ-aminobutyric acid(A )receptor subtype, α1β2γ2
BACKGROUND: Amino acids in the β subunit contribute to the action of general anaesthetics on GABA(A )receptors. We have now characterized the phenotypic effect of two β subunit mutations in the most abundant GABA(A )receptor subtype, α1β2γ2. RESULTS: The β2(N265M) mutation in M2 decreased the modula...
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| Vydáno v: | BMC Pharmacol |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BMC
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280653/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14613517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2210-3-13 |
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