Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

Gene activation and repression regulated by acetylation and deacetylation represent a paradigm for the function of histone modifications. We provide evidence that, in contrast, histone H2B monoubiquitylation and its deubiquitylation are both involved in gene activation. Substitution of the H2B ubiqu...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Henry, Karl W., Wyce, Anastasia, Lo, Wan-Sheng, Duggan, Laura J., Emre, N.C. Tolga, Kao, Cheng-Fu, Pillus, Lorraine, Shilatifard, Ali, Osley, Mary Ann, Berger, Shelley L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2003
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280615/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14563679/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1144003
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