Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

Activation of hepatic stellate cells (HSC) results in their proliferation and in the secretion of extracellular matrix (ECM) proteins, which leads to hepatic fibrosis. microRNAs (miRNAs) have been shown to regulate various cell functions, such as proliferation, differentiation, and apoptosis. Hence,...

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Main Authors: Venugopal, Senthil K., Jiang, Joy, Kim, Tae-Hun, Li, Yong, Wang, Si-Si, Torok, Natalie J., Wu, Jian, Zern, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2010
Teme:
Liver and Biliary Tract
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806096/
https://ncbi.nlm.nih.gov/pubmed/19892940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00220.2009
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