Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

Activation of hepatic stellate cells (HSC) results in their proliferation and in the secretion of extracellular matrix (ECM) proteins, which leads to hepatic fibrosis. microRNAs (miRNAs) have been shown to regulate various cell functions, such as proliferation, differentiation, and apoptosis. Hence,...

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Detalhes bibliográficos
Main Authors: Venugopal, Senthil K., Jiang, Joy, Kim, Tae-Hun, Li, Yong, Wang, Si-Si, Torok, Natalie J., Wu, Jian, Zern, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806096/
https://ncbi.nlm.nih.gov/pubmed/19892940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00220.2009
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