The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

Yeast mother cell-specific aging constitutes a model of replicative aging as it occurs in stem cell populations of higher eukaryotes. Here, we present a new long-lived yeast deletion mutation,afo1 (for aging factor one), that confers a 60% increase in replicative lifespan. AFO1/MRPL25 codes for a pr...

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Hauptverfasser: Heeren, Gino, Rinnerthaler, Mark, Laun, Peter, von Seyerl, Phyllis, Kössler, Sonja, Klinger, Harald, Jarolim, Stefanie, Simon-Nobbe, Birgit, Hager, Matthias, Schüller, Christoph, Carmona-Gutierrez, Didac, Breitenbach-Koller, Lore, Mück, Christoph, Jansen-Dürr, Pidder, Criollo, Alfredo, Kroemer, Guido, Madeo, Frank, Breitenbach, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806038/
https://ncbi.nlm.nih.gov/pubmed/20157544
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