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Urea cycle regulation by mitochondrial sirtuin, SIRT5

Mammalian sirtuins have diverse roles in aging, metabolism and disease. Recently we reported a new function for SIRT5 in urea cycle regulation. Our study uncovered that SIRT5 localized to mitochondria matrix and deacetylates carbamoyl phosphate synthetase 1 (CPS1), an enzyme which is the first and r...

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Autors principals: Nakagawa, Takashi, Guarente, Leonard
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806029/
https://ncbi.nlm.nih.gov/pubmed/20157539
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