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Metabolic signals regulate SIRT1 expression

SIRT1 is a key metabolic regulator in response to nutrient availability. Here, Chalkiadaki and Guarente comment on a report published online this month in which J. Auwerx and colleagues show how SIRT1 transcription is controlled by the antagonistic actions of CREB and ChREBP in response to the energ...

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Autors principals: Chalkiadaki, Angeliki, Guarente, Leonard
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185348/
https://ncbi.nlm.nih.gov/pubmed/21941300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.179
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