Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells

Senescence is blocked in human cervical keratinocytes infected with high risk human papillomavirus (e.g. HPV type16). Viral oncoproteins HPV E6 and HPV E7 access the cell cycle via cellular p53 and retinoblastoma proteins respectively. Previously we have shown that HPV E7, not HPV E6, is also respon...

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Bibliografski detalji
Glavni autori: Allison, Simon J., Jiang, Ming, Milner, Jo
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2009
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806013/
https://ncbi.nlm.nih.gov/pubmed/20157519
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