HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes

Using conditional cell reprogramming, we generated a stable cell culture of an extremely rare and aggressive neuroendocrine cervical cancer. The cultured cells contained HPV-16, formed colonies in soft agar and rapidly produced tumors in immunodeficient mice. The HPV-16 genome was integrated adjacen...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yuan, Hang, Krawczyk, Ewa, Blancato, Jan, Albanese, Christopher, Zhou, Dan, Wang, Naidong, Paul, Siddartha, Alkhilaiwi, Faris, Palechor-Ceron, Nancy, Dakic, Aleksandra, Fang, Shuang, Choudhary, Sujata, Hou, Tung-Wei, Zheng, Yun-Ling, Haddad, Bassem R., Usuda, Yukari, Hartmann, Dan, Symer, David, Gillison, Maura, Agarwal, Seema, Wangsa, Danny, Ried, Thomas, Liu, Xuefeng, Schlegel, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381214/
https://ncbi.nlm.nih.gov/pubmed/28378747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45617
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