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GPCR 3D homology models for Ligand Screening: Lessons Learned from Blind Predictions of Adenosine A2a Receptor complex

Proteins of the G-protein coupled receptor (GPCR) family present numerous attractive targets for rational drug design, but also a formidable challenge for identification and conformational modeling of their 3D structure. A recently performed assessment of blind predictions of adenosine A2a receptor...

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Hlavní autoři: Katritch, Vsevolod, Rueda, Manuel, Lam, Polo Chun-Hung, Yeager, Mark, Abagyan, Ruben
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805832/
https://ncbi.nlm.nih.gov/pubmed/20063437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22507
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