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Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells
Accurate chromosome segregation during mitosis relies on the organization of microtubules into a bipolar spindle. Kinesin-5 proteins play an evolutionarily conserved role in establishing spindle bipolarity [1, 2] and clinical trials are currently evaluating inhibitors of human kinesin-5 (i.e. Eg5) f...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805786/ https://ncbi.nlm.nih.gov/pubmed/19931454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.10.056 |
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