Development of a Wilms’ tumor antigen-specific T-cell receptor for clinical trials: engineered patient’s T cells can eliminate autologous leukemia blasts in NOD/SCID mice

BACKGROUND: The Wilms’ tumor antigen (WT1) is an attractive target for immunotherapy of leukemia. In the past, we isolated and characterized the specificity and function of a WT1-specific T-cell receptor. The goal of this translational study was to develop a safe and efficient WT1-T-cell receptor re...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Xue, Shao-An, Gao, Liquan, Thomas, Sharyn, Hart, Daniel P., Xue, John Zhao, Gillmore, Roopinder, Voss, Ralf-Holger, Morris, Emma, Stauss, Hans J.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805729/
https://ncbi.nlm.nih.gov/pubmed/19679884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.006486
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados