Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry

BACKGROUND: The spike protein (S) of SARS Coronavirus (SARS-CoV) mediates entry of the virus into target cells, including receptor binding and membrane fusion. Close to or in the viral membrane, the S protein contains three distinct motifs: a juxtamembrane aromatic part, a central highly hydrophobic...

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Bibliographic Details
Main Authors: Corver, Jeroen, Broer, Rene, van Kasteren, Puck, Spaan, Willy
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805634/
https://ncbi.nlm.nih.gov/pubmed/20034394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-6-230
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