Ligand-specific regulation of the extracellular surface of a G protein coupled receptor

G protein coupled receptors (GPCRs) are seven transmembrane proteins that mediate the majority of cellular responses to hormones and neurotransmitters. They are the largest group of therapeutic targets for a broad spectrum of diseases. Recent crystal structures of GPCRs1,2,3,4,5 reveal structural co...

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Auteurs principaux: Bokoch, Michael P., Zou, Yaozhong, Rasmussen, Søren G. F., Liu, Corey W., Nygaard, Rie, Rosenbaum, Daniel M., Fung, Juan José, Choi, Hee-Jung, Thian, Foon Sun, Kobilka, Tong Sun, Puglisi, Joseph D., Weis, William I., Pardo, Leonardo, Prosser, R. Scott, Mueller, Luciano, Kobilka, Brian K.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805469/
https://ncbi.nlm.nih.gov/pubmed/20054398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08650
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