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Pd-Catalyzed N-Arylation of Secondary Acyclic Amides: Catalyst Development, Scope, and Computational Study

We report the efficient N-arylation of acyclic secondary amides and related nucleophiles with aryl nonaflates, triflates, and chlorides. This method allows for easy variation of the aromatic component in tertiary aryl amides. A new biaryl phosphine with P-bound 3,5-(bis)trifluoromethylphenyl groups...

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Autori principali: Hicks, Jacqueline D., Hyde, Alan M., Cuezva, Alberto Martinez, Buchwald, Stephen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805443/
https://ncbi.nlm.nih.gov/pubmed/19886610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9044357
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