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Higher susceptibility to halothane modulation in open- than in closed-channel α4β2 nAChR revealed by MD simulations
The neuronal α4β2 nicotinic acetylcholine receptor (nAChR) is a potential molecular target for general anesthetics. It is unclear, however, whether anesthetic action produces the same effect on the open and closed channels. Computations parallel to our previous open channel study (J. Phys. Chem. B,...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805416/ https://ncbi.nlm.nih.gov/pubmed/20014754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp908944e |
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