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Anionic Lipid and Cholesterol Interactions with α4β2 nAChR: Insights from MD Simulations
Anionic lipids and cholesterols (CHOL) are critical to the function of nicotinic acetylcholine receptors (nAChR). We investigated their interactions with an open- and closed-channel α4β2 nAChR by over 10-ns molecular dynamics simulations in a ternary lipid mixture of 1-palmitoyl-2-oleoyl phosphatidy...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698126/ https://ncbi.nlm.nih.gov/pubmed/19419220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp900714b |
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