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Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats

To explore the specific contribution of the C1 neurons to blood pressure (BP) control, we used an optogenetic approach to activate these cells in vivo. A lentivirus that expresses channelrhodopsin-2 (ChR2) under the control of the catecholaminergic neuron-preferring promoter PRSx8 was introduced int...

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Autors principals: Abbott, Stephen B G, Stornetta, Ruth L, Socolovsky, Carmela S, West, Gavin H, Guyenet, Patrice G
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805374/
https://ncbi.nlm.nih.gov/pubmed/19822543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.177535
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