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Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity.

Chimeric antibodies were constructed in which the murine variable region of anti-colorectal cancer monoclonal antibody CO17-1A was joined with human gamma 1, gamma 2, gamma 3, and gamma 4 constant regions. Human-mouse chimeric proteins were compared with the parental murine IgG2a antibody CO17-1A fo...

詳細記述

保存先:
書誌詳細
主要な著者: Steplewski, Z, Sun, L K, Shearman, C W, Ghrayeb, J, Daddona, P, Koprowski, H
フォーマット: Artigo
言語:Inglês
出版事項: 1988
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC280534/
https://ncbi.nlm.nih.gov/pubmed/3387441
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