Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity.

Chimeric antibodies were constructed in which the murine variable region of anti-colorectal cancer monoclonal antibody CO17-1A was joined with human gamma 1, gamma 2, gamma 3, and gamma 4 constant regions. Human-mouse chimeric proteins were compared with the parental murine IgG2a antibody CO17-1A fo...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Steplewski, Z, Sun, L K, Shearman, C W, Ghrayeb, J, Daddona, P, Koprowski, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3387441/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.13.4852
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!