Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity.

Chimeric antibodies were constructed in which the murine variable region of anti-colorectal cancer monoclonal antibody CO17-1A was joined with human gamma 1, gamma 2, gamma 3, and gamma 4 constant regions. Human-mouse chimeric proteins were compared with the parental murine IgG2a antibody CO17-1A fo...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Steplewski, Z, Sun, L K, Shearman, C W, Ghrayeb, J, Daddona, P, Koprowski, H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3387441/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.13.4852
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