Cationic Poly(amidoamine) Dendrimer Induces Lysosomal Apoptotic Pathway at Therapeutically Relevant Concentrations

Poly(amidoamine) (PAMAM) dendrimers carrying different amounts of surface amino groups were synthesized and tested for their effects on cellular cytotoxicity, lysosomal pH, and mitochondria-dependent apoptosis. In KB cells, the PAMAM dendrimers were taken up into the lysosomal compartment, and they...

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Bibliografiske detaljer
Main Authors: Thomas, Thommey P., Majoros, Istvan, Kotlyar, Alina, Mullen, Douglas, Banaszak Holl, Mark M., Baker, James R.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805189/
https://ncbi.nlm.nih.gov/pubmed/19924846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm900683r
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