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Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

Immune tolerance to tumors is often associated with accumulation of myeloid-derived suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In tumor-bearing mice, MDSCs can themselves facilitate the generation of tumor-specific Tregs. In this study, we demonstrate that ex...

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Autors principals: Pan, Ping-Ying, Ma, Ge, Weber, Kaare J., Ozao-Choy, Junko, Wang, George, Yin, Bingjiao, Divino, Celia M., Chen, Shu-Hsia
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805053/
https://ncbi.nlm.nih.gov/pubmed/19996287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1882
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