Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors

Aromatase (CYP19) is a critical enzyme for estrogen biosynthesis, and aromatase inhibitors (AIs) are established endocrine therapy for post-menopausal women with breast cancer. DNA samples were obtained from 52 women pre- and post-AI treatment in the neoadjuvant setting. 82 breast cancer and 19 norm...

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Hauptverfasser: Wang, Liewei, Ellsworth, Katarzyna A., Moon, Irene, Pelleymounter, Linda L., Eckloff, Bruce W., Martin, Yvette N., Fridley, Brooke L., Jenkins, Gregory D., Batzler, Anthony, Suman, Vera J., Ravi, Saranya, Dixon, J. Michael, Miller, William R., Wieben, Eric D., Buzdar, Aman, M.Weinshilboum, Richard, Ingle, James N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804935/
https://ncbi.nlm.nih.gov/pubmed/20048079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3224
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