The Amyloid Precursor Protein/Protease Nexin 2 Kunitz Inhibitor Domain Is a Highly Specific Substrate of Mesotrypsin

The amyloid precursor protein (APP) is a ubiquitously expressed transmembrane adhesion protein and the progenitor of amyloid-β peptides. The major splice isoforms of APP expressed by most tissues contain a Kunitz protease inhibitor domain; secreted APP containing this domain is also known as proteas...

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Detalhes bibliográficos
Main Authors: Salameh, Moh'd A., Robinson, Jessica L., Navaneetham, Duraiswamy, Sinha, Dipali, Madden, Benjamin J., Walsh, Peter N., Radisky, Evette S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804352/
https://ncbi.nlm.nih.gov/pubmed/19920152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057216
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