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NIH-3T3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca2+ mobilization.

NIH-3T3 cells transformed by the EJ-ras oncogene synthesize only 10-15% as much inositol 1,4,5-trisphosphate (InsP3) as control cells after stimulation with platelet-derived growth factor (PDGF). This is despite the fact that the basal (unstimulated) levels of InsP3 synthesized in control and EJ-ras...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Benjamin, C W, Connor, J A, Tarpley, W G, Gorman, R R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280425/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3288991/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.12.4345
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