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Loss of the Gata1 Gene IE Exon Leads to Variant Transcript Expression and the Production of a GATA1 Protein Lacking the N-terminal Domain

GATA1 is essential for the differentiation of erythroid cells and megakaryocytes. The Gata1 gene is composed of multiple untranslated first exons and five common coding exons. The erythroid first exon (IE exon) is important for Gata1 gene expression in hematopoietic lineages. Because previous IE exo...

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Autores principales: Kobayashi, Eri, Shimizu, Ritsuko, Kikuchi, Yuko, Takahashi, Satoru, Yamamoto, Masayuki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804226/
https://ncbi.nlm.nih.gov/pubmed/19854837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030726
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