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Thiamine Triphosphate Synthesis in Rat Brain Occurs in Mitochondria and Is Coupled to the Respiratory Chain

In animals, thiamine deficiency leads to specific brain lesions, generally attributed to decreased levels of thiamine diphosphate, an essential cofactor in brain energy metabolism. However, another far less abundant derivative, thiamine triphosphate (ThTP), may also have a neuronal function. Here, w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gangolf, Marjorie, Wins, Pierre, Thiry, Marc, El Moualij, Benaïssa, Bettendorff, Lucien
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804207/
https://ncbi.nlm.nih.gov/pubmed/19906644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054379
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