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Direct Demonstration of Half-of-the-sites Reactivity in the Dimeric Cytochrome bc(1) Complex: ENZYME WITH ONE INACTIVE MONOMER IS FULLY ACTIVE BUT UNABLE TO ACTIVATE THE SECOND UBIQUINOL OXIDATION SITE IN RESPONSE TO LIGAND BINDING AT THE UBIQUINONE REDUCTION SITE

We previously proposed that the dimeric cytochrome bc(1) complex exhibits half-of-the-sites reactivity for ubiquinol oxidation and rapid electron transfer between bc(1) monomers (Covian, R., Kleinschroth, T., Ludwig, B., and Trumpower, B. L. (2007) J. Biol. Chem. 282, 22289–22297). Here, we demonstr...

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Autori principali: Castellani, Michela, Covian, Raul, Kleinschroth, Thomas, Anderka, Oliver, Ludwig, Bernd, Trumpower, Bernard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804198/
https://ncbi.nlm.nih.gov/pubmed/19892700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072959
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