Oscillatory Flow-induced Proliferation of Osteoblast-like Cells Is Mediated by α(v)β(3) and β(1) Integrins through Synergistic Interactions of Focal Adhesion Kinase and Shc with Phosphatidylinositol 3-Kinase and the Akt/mTOR/p70S6K Pathway

Interstitial flow in and around bone tissue is oscillatory in nature and affects the mechanical microenvironment for bone cell growth and formation. We investigated the role of oscillatory shear stress (OSS) in modulating the proliferation of human osteoblast-like MG63 cells and its underlying mecha...

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Hlavní autoři: Lee, Ding-Yu, Li, Yi-Shuan J., Chang, Shun-Fu, Zhou, Jing, Ho, Hui-Min, Chiu, Jeng-Jiann, Chien, Shu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804177/
https://ncbi.nlm.nih.gov/pubmed/19889638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010512
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