Inhibition of Inducible Nitric Oxide Synthase Expression by a Novel Small Molecule Activator of the Unfolded Protein Response

The transcription of inducible nitric oxide synthase (iNOS) is activated by a network of proinflammatory signaling pathways. Here we describe the identification of a small molecule that downregulates the expression of iNOS mRNA and protein in cytokine-activated cells and suppresses nitric oxide prod...

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Bibliographic Details
Main Authors: Symons, Kent T, Massari, Mark E, Dozier, Sara J, Nguyen, Phan M, Jenkins, David, Herbert, Mark, Gahman, Timothy C, Noble, Stewart A, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A
Format: Artigo
Language:Inglês
Published: Bentham Open 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803434/
https://ncbi.nlm.nih.gov/pubmed/20161838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875397300802010001
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