Inhibition of Inducible Nitric Oxide Synthase Expression by a Novel Small Molecule Activator of the Unfolded Protein Response

The transcription of inducible nitric oxide synthase (iNOS) is activated by a network of proinflammatory signaling pathways. Here we describe the identification of a small molecule that downregulates the expression of iNOS mRNA and protein in cytokine-activated cells and suppresses nitric oxide prod...

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Bibliografiske detaljer
Main Authors: Symons, Kent T, Massari, Mark E, Dozier, Sara J, Nguyen, Phan M, Jenkins, David, Herbert, Mark, Gahman, Timothy C, Noble, Stewart A, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A
Format: Artigo
Sprog:Inglês
Udgivet: Bentham Open 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803434/
https://ncbi.nlm.nih.gov/pubmed/20161838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875397300802010001
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