The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described. The crystal structures of the substrate-free and substrate-bound C...

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Bibliografiske detaljer
Main Authors: Shafaati, Marjan, Mast, Natalia, Beck, Olof, Nayef, Rima, Heo, Gun Young, Björkhem-Bergman, Linda, Lütjohann, Dieter, Björkhem, Ingemar, Pikuleva, Irina A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803233/
https://ncbi.nlm.nih.gov/pubmed/19474457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900174-JLR200
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