The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described. The crystal structures of the substrate-free and substrate-bound C...

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Main Authors: Shafaati, Marjan, Mast, Natalia, Beck, Olof, Nayef, Rima, Heo, Gun Young, Björkhem-Bergman, Linda, Lütjohann, Dieter, Björkhem, Ingemar, Pikuleva, Irina A.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803233/
https://ncbi.nlm.nih.gov/pubmed/19474457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900174-JLR200
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