The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described. The crystal structures of the substrate-free and substrate-bound C...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shafaati, Marjan, Mast, Natalia, Beck, Olof, Nayef, Rima, Heo, Gun Young, Björkhem-Bergman, Linda, Lütjohann, Dieter, Björkhem, Ingemar, Pikuleva, Irina A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803233/
https://ncbi.nlm.nih.gov/pubmed/19474457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900174-JLR200
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