Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. T...

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Hauptverfasser: Swirski, Filip K., Nahrendorf, Matthias, Etzrodt, Martin, Wildgruber, Moritz, Cortez-Retamozo, Virna, Panizzi, Peter, Figueiredo, Jose-Luiz, Kohler, Rainer H., Chudnovskiy, Aleksey, Waterman, Peter, Aikawa, Elena, Mempel, Thorsten R., Libby, Peter, Weissleder, Ralph, Pittet, Mikael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803111/
https://ncbi.nlm.nih.gov/pubmed/19644120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1175202
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