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An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer therapy. TNP-470, a fumagillin analog, is among the most potent and broad-spectrum angiogenesis inhibitors. However, a major clinical limitation is its poor oral availability and short half-life, necessitatin...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2803109/ https://ncbi.nlm.nih.gov/pubmed/18587385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1415 |
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