Ablation of ARNT/HIF1β in Liver Alters Gluconeogenesis, Lipogenic Gene Expression, and Serum Ketones

We have previously shown that expression of the transcription factor ARNT/HIF1β is reduced in islets of humans with type 2 diabetes. We have now found that ARNT is also reduced in livers of diabetics. To study the functional effect of its reduction, we created mice with liver-specific ablation (L-AR...

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Main Authors: Wang, Xiaohui L., Suzuki, Ryo, Lee, Kevin, Tran, Thien, Gunton, Jenny E., Saha, Asish K., Patti, Mary-Elizabeth, Goldfine, Allison, Ruderman, Neil B., Gonzalez, Frank J., Kahn, C. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803070/
https://ncbi.nlm.nih.gov/pubmed/19416713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.04.001
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